Paracetamol has analgesic and antipyretic activity. The drug blocks cyclooxygenase I and II predominantly in the central nervous system, affecting thermoregulation, and pain centers. In inflamed tissues cellular peroxidase neutralize the effect of paracetamol on cyclooxygenase, which explains the almost complete absence of his anti-inflammatory effect. The drug has no negative impact on the water-salt metabolism (sodium and water retention) and the digestive tract mucosa due to the lack of influence on the synthesis of prostaglandins in peripheral tissues. The possibility of formation of methemoglobin – is unlikely.
moderately or weakly expressed bituminous mix testosterone pain (headache, toothache, migraine pain, neuralgia, muscle pain, back pain, pain in trauma and burns, sore throat, painful menstruation).
Increased body temperature in cold and other infectious diseases -vospalitelnyh.
- Hypersensitivity to paracetamol or any other component of the formulation.
- Children under 9 years of age (weight not less than 35 kg)
With care – renal and / or hepatic failure, congenital hyperbilirubinemia (Gilbert syndrome, Dubinin-Johnson and Rotor), viral hepatitis, alcoholic liver disease, alcoholism, lack of glucose-6-phosphate dehydrogenase, pregnancy, lactation, old age.
DOSAGE AND ADMINISTRATION
The tablet dissolved in a glass of water (200 ml) and drink after 1 -2 hours after a meal. Typically used 1-2 tablets 2-3 times a day at intervals of at least 4 hours.
The maximum single dose for adults and adolescents over 12 years is 2 tablets (1 g) daily – 8 tablets (4 g).
Children (9-12 years); 1 tablet up to 4 times a day, if necessary. The interval between doses – at least 4 hours, a single dose can be administered no more than 4 times (4 tablets) for 24 hours.
Patients with impaired hepatic or renal function and in elderly patients with an interval between doses of the drug should be at least 8 hours and the daily dose should be reduced.
The duration of intake of not more than 5 days in the appointment as an analgesic and 3 days as antipyretic. The increase in the daily dose bituminous mix testosterone or duration of treatment are possible only under medical supervision.
The drug was well tolerated at recommended doses.
Sometimes there may be an allergic reaction in the form of a skin rash, itching, angioedema. Rarely – a violation of hematopoiesis (anemia, thrombocytopenia, methemoglobinemia).
With prolonged use at doses considerably higher than recommended, increasing the likelihood of human liver and kidneys, requires monitoring of peripheral blood picture.
symptoms: pale skin, anorexia, nausea, vomiting; gepatonekroz (necrosis severity is directly dependent on the degree of overdose). The toxic effect of the drug in adults is possible after receiving more than 10-15 g of paracetamol: increased activity of “liver” transaminases, increased prothrombin time (after 12-48 hours); detailed clinical picture of liver damage manifests itself in 1-6 days. Rarely hepatic dysfunction develops lightning speed and can be complicated by renal insufficiency (tubular necrosis).
INTERACTION WITH OTHER DRUGS
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication with small overdoses. Ethanol contributes to the development of acute pancreatitis. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
Paracetamol reduces the effectiveness of uricosuric drugs.
With continued feverish syndrome, during treatment with paracetamol for more than 3 days, and pain syndrome – more than 5 days require a doctor’s consultation.
Distorts the performance of laboratory tests for the quantitative determination of uric acid in the plasma.
In order to prevent liver bituminous mix testosterone toxicity of paracetamol should not be combined with alcohol intake, and take people prone to chronic alcohol consumption.
The risk of liver damage increases in patients with alcoholic hepatosis.
Prolonged use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver.
Flyutabs contains 451 mg of sodium per tablet which should be taken into account in patients on a strict low-salt diet.