Simultaneous multiple fluconazole and hydrochlorothiazide may lead to an increase in concentration of fluconazole in blood plasma by 40%. The effect of this severity does not require changes in dosage regimen of fluconazole in patients receiving concomitant diuretics, but a doctor should take this into account.
Rifampicin. The combination with rifampicin leads to Ap28 pancake mix gnc testosterone reduction (area under the curve “concentration-time”) by 25% and shortened the half-life of fluconazole of 20% plasma. Therefore, patients receiving concomitant rifampicin, the dose of fluconazole is expedient to increase. Fluconazole is a potent inhibitor of the and a moderate inhibitor of the isoenzyme . In addition to these further effects, there is a risk increase in plasma concentration and other drugs, mstaboliziruemyh isoenzymes while taking a flukoiazolom. Therefore, caution should be exercised with concomitant use of the following drugs steroids deca, and similar combinations of patients if necessary should be under close medical supervision. Note that the inhibiting effect of fluconazole persists 4-5 days after discontinuation of therapy due to the long half-life.
Alfentanil. There decrease in clearance and volume of distribution, the increase in half-life of alfentanil. This may be due to inhibition of CYP3A4 flukoiazolom. You may need a dosage adjustment alfentanil. Amitriptyline, nortriptyline. The effect of increasing. The concentration of 5-nortriptyline p28 pancake mix gnc testosterone may be measured at the start of combination therapy with fluconazole and one week after the start of treatment. If necessary to adjust the dose of amitriptyline / nortriptyline. Amphotericin B. In studies in mice (including immunosuppressed) were noted following results: a small additive antifungal effect in systemic infection caused by C. albicans, no interaction with intracranial infection caused Cryplococcus neoformans and antagonism in systemic infection by A. fimigatus. The clinical significance of these results phenylpropionate is not clear. In the application of fluconazole and other antifungals (azole derivatives) with warfarin increases protrombinovos time (an average of 12%). Perhaps bleeding (hematoma, bleeding from the nose and gastrointestinal tract, hematuria, melena). Patients receiving anticoagulants kumariiovye, you must constantly monitor the prothrombin time during treatment and within 8 days after the simultaneous application. You should also evaluate the feasibility of dose adjustment of warfarin. Azithromycin. In an application inside of fluconazole in a single dose of 800 mg of azithromycin in a single dose of 1200 mg expressed pharmacokinetic interaction between the two drugs is not established.
Benzodiazepines. (Short-acting). After oral administration of midazolam, fluconazole significantly increases the concentration of midazolam and psychomotor effects and this effect is more pronounced after receiving fluconazole inside than when used intravenously. If necessary, concomitant therapy with benzodiazepines in patients taking fluconazole be observed in order to assess the feasibility of the corresponding dose reduction benzodiazepine. When simultaneous administration of a single dose of triazolam, fluconazole triazolam AUC increases by approximately 50%, C max – 25-50% and elimination half-life at 25 50% due to the inhibition of metabolism of triazolam. You may need dose adjustment of triazolam. Carbamazepine. Fluconazole inhibits the metabolism of carbamazepine and increase proviron dosage its serum concentration by 30%. It is necessary to take into account the risk of developing carbamazepine toxicity. It will be appreciated the need carbamazepine dose adjustment depending on the concentration / effect. Calcium channel blockers. Certain calcium channel antagonists (nifedipine, isradipine, amlodipine, verapamil and felodipine) are metabolized isoenzyme p28 pancake mix gnc testosterone. Fluconazole increases the systemic exposure of calcium channel antagonists. Recommended control side effects. Cyclosporine.It is recommended to monitor the blood concentration of cyclosporine in patients receiving fluconazole as patients receiving a transplanted kidney Fluconazole, 200 mg / day results in a slow increase in the plasma concentration of cyclosporine. However, when multiple dose Fluconazole, 100 mg / day of cyclosporine concentration changes in bone marrow transplant recipients was observed.Cyclophosphamide. With simultaneous use of cyclophosphamide and fluconazole marked increase in serum bilirubin and creatinine concentrations. A combination of drugs is possible, taking into account the risk of data breaches. Fentanyl. There are reports of one death, possibly due to the simultaneous reception of fentanyl and fluconazole. It is assumed that the disturbances associated with fentanyl intoxication.