It was shown that fluconazole significantly lengthens excretion of fentanyl. Note that increasing the concentration of fentanyl can lead to inhibition of respiratory function. Galofantina can increase the concentration in plasma due to the inhibition of isozyme testosterone mix 500 phoenix. While the use of fluconazole, as well as with other antifungals azole may develop arrhythmias of ventricular tahisistolicheskoy type “pirouette”, so the combined use of them is not recommended.
Inhibitors of MMC-CoA reductase. With the simultaneous use of fluconazole with inhibitors reductase, metabolized isoenzyme (such as atorvastatin and simvastatin) or isoenzyme (fluvastatin), the risk of myopathy and rhabdomyolysis is increased. If necessary, concurrent therapy these drugs, patients should be monitored in order to detect symptoms of myopathy and rhabdomyolysis. It is necessary to monitor the concentration of in the event of a significant increase in the concentration of or if diagnosed or suspected on the development of myopathy or rhabdomyolysis, therapy with inhibitors reductase inhibitors should be discontinued.
Losartan. Fluconazole inhibits the metabolism of losartan to its active metabolite, which responsible for most of the effects associated with antagonism of the angiotensin-II receptor. A regular control of blood pressure.Methadone. Fluconazole may increase the plasma concentrations of methadone. You may need correction of the dose of methadone. Nonsteroidal anti-inflammatory drugs . Of flurbiprofen increased 23% pa and 81%, respectively. Similarly, tof the pharmacologically active isomer were increased by 15% and 82% respectively, while the application of fluconazole with racemic ibuprofen (400mg). With simultaneous use of fluconazole in a dose of 200 mg / day of celecoxib in a dose of 200 mg celecoxib increased na 68% and 134%, respectively. This combination may reduce the dose of celecoxib twice. Despite the lack of dedicated research, fluconazole may increase the systemic exposure of other metabolized isoenzyme (naproxen, lornoxicam, meloxicam, diclofenac). You may need a dosage adjustment . With simultaneous use of testosterone mix 500 phoenix and fluconazole patients should be under close medical supervision in order to identify and monitor adverse events and toxicities associated with .
Oral contraceptives. In an application combining oral contraceptives with fluconazole at a dose of 50 mg significantly effect on hormone levels has been established. With a daily intake of 200 mg of fluconazole AUC of ethinyl estradiol and levonorgestrel increased by 40% and 24%, respectively. When receiving 300 mg fluconazole once weekly ethinyl estradiol and norethindrone increased by 24% and 13% respectively. Thus, repeated use of fluconazole in these doses is unlikely to affect the efficacy of combined oral contraceptive. Phenytoin. Simultaneous administration of fluconazole and phenytoin can lead to an increase in the plasma concentration of phenytoin to a clinically significant degree.Therefore, if necessary, the joint use of these drugs need to monitor the concentration of phenytoin with the dose adjusted to maintain drug levels within the therapeutic range.
Prednisone. There are reports on the development of acute adrenal insufficiency of the patient after liver transplantation to cancel background fluconazole after three months of therapy. Presumably, the termination of fluconazole therapy caused the increase of isoenzyme activity testosterone mix 500 phoenix, leading to increased metabolism of prednisone. Patients receiving combination therapy with prednisone and fluconazole should be under close medical supervision at the abolition of receiving fluconazole for the purpose of assessing the state of the adrenal cortex. Rifabutin. There have been reports about the interaction of fluconazole and rifabutin, accompanied by an increase in serum concentrations of the latter up to 80%. With simultaneous use of fluconazole and rifabutin uveitis cases are described.